Spectrométrie de Masse pour la Biologie

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Une approche multidisciplinaire et intégrative pour comprendre l'assemblage, la structure et la dynamique d'une plateforme de queue contractile · 2017

Publications HAL récentes repérées

• Direct carbapenemase typing from disc diffusion antibiograms with MALCA (MAchine Learning CArbapenemase) · 2026

  Résumé de la publication : Carbapenemase-producing Enterobacterales (CPE) present limited therapeutic options. Optimal treatment requires identifying the carbapenemase type, often requiring confirmatory testing beyond routine susceptibility results. We develop MALCA, a machine-learning classifier that uses routine disc diffusion antibiogram results to directly detect CPE and identify the…

• β-lactam susceptibility testing of ampicillin-susceptible non-faecalis enterococcal clinical isolates in France · 2026

  Résumé de la publication : Objectives: To assess the epidemiological susceptibility distribution of five β-lactam antibiotics for contemporary clinical isolates of non-faecalis Enterococcus species categorized as susceptible to ampicillin and to evaluate the performance of gradient diffusion (GD) tests compared to broth microdilution (BMD), the reference method…

• Arf1 is involved in Neisseria meningitidis-induced cortical branched F-actin network reorganization · 2026

  Résumé de la publication : Cells experience external forces that deform the plasma membrane to which they adapt by reorganizing their actin cytoskeleton. Here, using the extracellular bacterium Neisseria meningitidis as a model system, we explore how this bacterium reorganizes the cortical actin cytoskeleton subsequently to mechanical…

• Differential formation of nitrate-responsive mycobacterial intracytoplasmic membranes during Mycobacterium tuberculosis infection · 2026

  Résumé de la publication : Subcellular compartmentalization of metabolic processes is a main feature of prokaryotic and eukaryotic architecture. Environmental bacteria generate intracytoplasmic membranes (ICMs) as a crucial strategy to adapt their metabolism to environmental changes. While pathogenic intracellular bacteria also perceive various stressful stimuli during host…

• Pneumococcus uses COMMD2 to alter host cellular immunity · 2026

  Résumé de la publication : NF-κB driven cellular immunity is essential for both pro- and anti-inflammatory responses to microbes, which makes it one of the most frequently targeted pathways by bacteria during pathogenesis. How NF-κB tunes the epithelial response to Streptococcus pneumoniae across the spectrum of commensal…