Unité Polarité Cellulaire, Migration et Cancer

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Vimentin loss inhibits DNA damage responses and promotes cancer cell survival · 2026

  Résumé de la publication : Vimentin intermediate filaments are a hallmark of aggressive tumours and are widely linked to invasion and EMT, yet how vimentin-dependent mechanics shape genome maintenance and therapy response is unclear. Here we show that vimentin, particularly under compressive load, promotes DNA repair competence.…

• Microtubule‐associated NAV3 regulates invasive phenotypes in glioblastoma cells · 2025

  Résumé de la publication : Glioblastomas are aggressive brain tumors for which effective therapy is still lacking, resulting in dismal survival rates. These tumors display significant phenotypic plasticity, harboring diverse cell populations ranging from tumor core cells to dispersed, highly invasive cells. Neuron navigator 3 (NAV3), a…

• Intratumoral Heterogeneity of Vimentin Modulates Nuclear Mechanotransduction, DNA Damage Response and Cancer Cell Survival · 2025

  Résumé de la publication : Vimentin, a major intermediate filament protein, is essential for maintaining cellular integrity and regulating cytoskeletal dynamics. Its upregulation is a hallmark of epithelial-to-mesenchymal transition (EMT), a process that enhances cancer cell migration, invasion, and metastatic potential. However, single-cell transcriptomic analyses of glioblastoma,…

• Microtubule-Targeting Agents: Advances in Tubulin Binding and Small Molecule Therapy for Gliomas and Neurodegenerative Diseases · 2025

  Résumé de la publication : Microtubules play a key role in cell division and cell migration. Thus, microtubule-targeting agents (MTAs) are pivotal in cancer therapy due to their ability to disrupt cell division microtubule dynamics. Traditionally divided into stabilizers and destabilizers, MTAs are increasingly being repurposed for…

• Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14 · 2025

  Résumé de la publication : Glioblastoma (GBM), the most aggressive primary brain tumor, is marked by high invasiveness that enables resistance to current therapies. Single-cell RNA sequencing analysis reveals that elevated expression of glial intermediate filament (IF) genes correlates with pro-invasive markers in GBM samples. Notably, vimentin…