Pathobiologie et thérapie des maladies du foie

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Hepatitis D Virus: Enigmas and Gaps of Knowledge · 2026

  Résumé de la publication : Hepatitis D virus (HDV) is a very peculiar virus that shares many characteristics with plant viroids. One of its unique characteristics is the requirement for the presence of a helper virus for its replication, and in particular enveloping its virion, a role…

• Plasma exchange as potential treatment of severe immune checkpoint inhibitor-induced hepatitis · 2026

  Résumé de la publication : Background & Aims: Immune checkpoint inhibitors (ICIs) improve cancer survival but can cause severe immune-related hepatitis. Standard therapy with corticosteroids and second-line agents such as mycophenolate mofetil fails in some cases. Therapeutic plasma exchange (TPE) has been suggested as rescue therapy, but…

• Functional immune responses induced by a capsid assembly modulator in chronic hepatitis B virus-infected humanized mice · 2026

  Résumé de la publication : Current treatment strategies for hepatitis B virus (HBV) are lifelong and rarely curative. Finite therapeutic strategies aim to restore efficient immune responses in chronically infected patients for functional cures. Here, we investigate the impact of treatment with the capsid assembly modulator (CAM)…

• Invasive aspergillosis in liver transplant recipients in France (2007–21): a nationwide, retrospective, matched case–control study · 2026

  Résumé de la publication : Background Invasive aspergillosis is a rare but severe complication of liver transplantation. Incidence varies from 1·2% to 5·6% and mortality is greater than 50%. Few studies have investigated this complication. We aimed to describe cases of, and identify the factors associated with,…

• Low Depth Epigenetic Mapping of Maturation Versus Retrodifferentiation in HepaRG Cells · 2026

  Résumé de la publication : Background: Long-read, single-CpG-resolution sequencing is redefining the information-to-depth ratio in epigenomics. While conventional methylome analysis often requires high coverage, we propose a scalable pipeline designed to extract high-density regulatory logic from shallow sequencing data. Methods: By utilizing the progenitor-like HepaRG cell line…