Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire (UR 7296)

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Is AMP‐activated protein kinase activation a central mechanism of cardio‐metabolic outcomes after metabolic and bariatric surgery? · 2026

  Résumé de la publication : Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of…

• Nicotine alters alveolar-barrier integrity by blocking autophagy and occludin trafficking · 2026

  Résumé de la publication : Tobacco smoke inhalation disrupts the integrity of the alveolar-capillary barrier (ACB) and contributes to the pathogenesis of multiple chronic pulmonary diseases as chronic obstructive pulmonary disease (COPD). Nicotine, a major component of both cigarette smoke and electronic cigarette (e-cigarette) aerosol, is predominantly…

• French-Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Gene Panel Analysis Through Genotyping or Sequencing in Pharmacogenetics · 2026

  Résumé de la publication : BACKGROUND: The implementation of pharmacogenetics in clinical practice increasingly relies on multigene panels. OBJECTIVES: The objective of this study is to develop harmonized recommendations for the design and analytical implementation of multigene pharmacogenetic panels, defining clinically relevant genes and associated regions of…

• Mise en place de méthodologies analytiques et de modèles cellulaires permettant l'identification d'éléments potentiellement toxiques présents dans l’aérosol d'e-cigarette · 2025

  Résumé de la publication : Les nouveaux systèmes de délivrance de nicotine, dont la cigarette électronique (CE), sont régulièrement présentés comme des outils de substitution nicotinique. Les autorités de santé restent prudentes quant à l’utilisation de tels dispositifs étant donné le manque de données toxicologiques. Mon projet…

• A Cross‐Sectional Evaluation of Cardiovascular and Metabolic Functions During Aging and Pregnancy in the Cynomolgus Monkey · 2025

  Résumé de la publication : Background: Cardiovascular and hemodynamic status can both be modified by cardiovascular risk factors which themselves depend on housing conditions. Methods: Cynomolgus macaques maintained in large enclosures allowing them to perform physical exercise and social interactions were evaluated for cardiovascular and metabolic parameters…