Unité de biologie fonctionnelle et adaptative

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Une stratégie thérapeutique pour le diabète de type 2 par des nanoparticules multiifonctionnalisées ciblant l'agrégation de l'amyline et les cellules pancréatiques · 2026
• Entraînement des neurones du noyau arqué de l’hypothalamus pour le contrôle de la flexibilité métabolique · 2026
• Régulation métabolique de l’expression cérébrale de DYRK1A et son impact sur l’homéostasie du glucose · 2026

Publications HAL récentes repérées

• Sirtuin inhibition by plumbagin connects protein acetylation to cell division · 2026

  Résumé de la publication : Naphthoquinones interfere with biological systems and exhibit pharmaceutical properties. As an electrophile, the naphthoquinone plumbagin may react with nucleophiles, mainly thiols, and form covalent adducts. Here, we have further characterized the effects of plumbagin in HeLa cells. First, we demonstrate that plumbagin…

• Inhibition of peripheral CB 1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis · 2026

  Résumé de la publication : Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB 1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects. Peripherally restricted CB 1 receptor antagonists offer…

• Foundations of Gerophysics · 2026

  Résumé de la publication : The inaugural Global Conference on Gerophysics convened 160 researchers across physics, biology, computation, and medicine in Singapore on March 5-6, 2025. With 31 speakers, the two-day event explored how physical laws, and quantitative principles unify aging science, linking biological processes to longevity…

• The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events · 2026

  Résumé de la publication : Reward processes have traditionally been ascribed to dopamine (DA)–associated circuits. While external stimuli, such as food and drugs of abuse, are activators of DA-neuron activity, growing evidence indicates that interoceptive signals also play a critical role. Among these, the gut-brain vagal axis…

• Interrégulations entre olfaction et métabolisme énergétique dans l’obésité et le diabète de type 2 · 2026

  Résumé de la publication : This review highlights the crucial role of olfaction in regulating energy homeostasis. Neurons in the olfactory system stimulate the limbic and hedonic pathways involved in food-related behaviors. These neurons are modulated by the body’s energy metabolism status, which they, in turn, help…