Unité Plasticité du Génome bactérien

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Etude de l'impact des intégrons chromosomiques sur l'évolution des bactéries · 2021
• Novel interventions for eliminating one-health mobile antimicrobial resistance genes from human and animal microbiomes · 2021

Publications HAL récentes repérées

• Anopheles resistance to deltamethrin can be caused by the increased abundance of an enteric Aeromonas taxon · 2026

  Résumé de la publication : The enteric bacteriome of Anopheles mosquito vector has been linked with its vectorial competence, however, its influence on insecticide resistance is poorly understood. We found that the depletion of the bacterial microbiome in susceptible Anopheles strains, resulting from antibiotic treatment, led to…

• Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome · 2026

  Résumé de la publication : Bacterial genomes frequently harbor extrachromosomal replicons (ERs) that promote genome plasticity and adaptation, ranging from small plasmids to chromosome-scale replicons. In a few model organisms, including Vibrio cholerae and Agrobacterium tumefaciens , large ERs are coordinated with chromosome replication and cell-cycle organization…

• Anopheles resistance to deltamethrin can be caused by the increased abundance of an enteric Aeromonas taxon · 2026

  Résumé de la publication : ABSTRACT The enteric bacteriome of Anopheles mosquito vectors has been linked with vectorial competence; however, its influence on insecticide resistance is poorly understood. We found that antibiotic treatment—administered either through sugar feeding (penicillin/streptomycin and gentamicin) or via a blood meal (amoxicillin)—which depleted…

• Antibiotics stimulate protein transfer to persister cells · 2026

  Résumé de la publication : The exchange of biological matter between bacterial cells drives adaptation and evolution. However, whether bacteria can exchange functional proteins remains unclear. In this work, we found that antibiotic treatment can induce vesicle-mediated horizontal protein transfer within and between bacterial species. We developed…

• Bacterial extracellular vesicles promote membrane repair and tolerance to polymyxin B · 2026

  Résumé de la publication : Bacterial extracellular vesicles (EVs) are nanosized lipid structures released under stress, yet their interactions with antibiotics remain poorly understood. We tracked real-time interactions between Escherichia coli , EVs, and fluorescent polymyxin B (Pmb) using single-cell imaging and cytometric approaches. EVs rapidly sequester…