LABORATOIRE DE PHYSIOLOGIE CELLULAIRE ET MOLECULAIRE - UR UPJV 4667

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Evaluation of the Antioxidant Potential and Selective Cytotoxicity of Fumaria agraria Alkaloids Against Human Breast Cancer Cells · 2026

  Résumé de la publication : Aim/Background This study aimed to investigate the antioxidant capacity, hemolytic effect, and cytotoxic potential of the alkaloid fraction isolated from Fumaria agraria , with an emphasis on its possible use as a therapeutic agent against cancer cells. Materials and Methods The antioxidant…

• pH-Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma. · 2026

  Résumé de la publication : Aim: Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid-base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and…

• Advanced integrated human in vitro approach to explore gut-brain barrier interactions with gut microbiota metabolites and pesticides · 2026

  Résumé de la publication : The gut microbiota (GM) plays a central role in host barrier homeostasis. Alterations in GM due to chronic dietary pesticide residues can have far-reaching consequences on human health. Although in vitro models are increasingly used to study organophosphate effects, especially Chlorpyrifos (CPF),…

• Quality-driven divisive K-Means: A new clustering strategy for MALDI imaging data for a more precise and less biased characterization of complex biological tissues · 2026

  Résumé de la publication : Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) has become the foremost technique for molecular characterization of complex biological tissues, owing to its unparalleled sensitivity, broad molecular coverage, and high spatial resolution. While targeted analysis is traditionally dominated MALDI imaging workflows, the inherent…

• Unraveling the Connection Between Ion Channels and Pancreatic Stellate Cell Activation · 2025

  Résumé de la publication : Quiescent pancreatic stellate cells (PSCs) represent only a very low proportion of the pancreatic tissue, but their activation leads to stroma remodeling and fibrosis associated with pathologies such as chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). PSC activation can be induced by…