INSTITUT IMAGINE

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Organoïdes cutanés pour la modélisation et le développement des approches d’édition génique des formes Simples, Jonctionnelles et Dystrophiques d’Epidermolyse Bulleuse · 2026
• Thérapie génique in vivo pour les ß-hémoglobinopathies · 2026
• Stratégie intégrée pharmacologique basée sur des biomarqueurs de signalisation afin de traiter les ciliopathies · 2026

Publications HAL récentes repérées

• Subdiffusive fractional limit of a jump-renewal equation · 2027

  Résumé de la publication : In this paper, we consider an age-structured jump model that arises as a description of continuous time random walks with infinite mean waiting time between jumps. We prove that under a suitable rescaling, this equation converges in the long time large scale…

• Long‐term outcome after allogeneic stem cell transplantation for GATA2 deficiency: An analysis of 67 adults and children from France and Belgium · 2026

  Résumé de la publication : Modalities and timing of haematopoietic stem cell transplant (HSCT) in patients with GATA2 deficiency are still subject to debate. On June 2022, 67 patients (median age 20.6 years) underwent a first allogeneic HSCT among 21 centres. Indications for HSCT were myelodysplastic syndrome…

• In vivo CAR therapies: Turning the patient into their own CAR factory · 2026

  Résumé de la publication : Over the past decade, ex vivo autologous chimeric antigen receptor (CAR)‐T‐cell therapies have reshaped the treatment of B‐cell malignancies. Despite their remarkable clinical efficacy, their application remains limited by complex manufacturing processes, demanding logistics, long turnaround times, and substantial costs. In vivo…

• Lymphedema in patients with X-linked severe combined immunodeficiency · 2026

  Résumé de la publication : Background: IL2RG and JAK3 mutations cause T-cell–negative, B-cell–positive, natural killer cell–negative severe combined immunodeficiency (SCID). Cell therapies such as hematopoietic stem cell transplantation (or gene therapy for IL2RG deficiency) can effectively restore T-cell immunity but—when performed without myeloablation—may leave residual immune defects.…

• The seen and unseen facets of Dravet syndrome across the disease trajectory: Insights from European ethnographic research · 2026

  Résumé de la publication : Background We investigated the lived experiences of individuals within the ecosystem of Dravet syndrome (DS) (patients, families, healthcare professionals, patient representatives) to gain a holistic understanding of the reality of caring for an individual with DS. Methods and Results Using ethnographic methodology,…