Virologie structurale

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Études structurelles sur la protéine de fusion d'un rétrovirus endogène impliqué dans le vieillissement et le cancer. · 2026
• CHARACTERIZATION D'UN COMPLEXE PRO-INFLAMMATOIRE FORME ENTRE LA PROTEINE NS1 DU VIRUS DE LA DENGUE ET LES PARTICULES LIPOPROTEIQUES DE HAUTE DENSITE · 2023
• Analyse de la structure-fonction des ligands du stade sanguin de Plasmodium vivax pour l'invasion · 2021

Publications HAL récentes repérées

• Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections · 2026

  Résumé de la publication : Autoantibodies neutralizing type-I interferons (AAN-I-IFNs) emerge as global, common, and strong determinants of a growing number of severe viral diseases. We report that AAN-I-IFNs+ patients with life-threatening COVID-19 pneumonia harbor circulating type-I IFN-specific B cells indistinguishable from patients bearing T cell tolerance…

• Temperature-dependent replication and sensitivity to innate immunity of human coronavirus HKU1 · 2026

  Résumé de la publication : The human coronavirus HKU1, causing common colds and occasionally severe illness, remains largely uncharacterized because it has not been successfully grown on immortalized cells. Here, we identify Caco2 cells overexpressing TMPRSS2, the HKU1 receptor, as being highly permissive to infection. HKU1 replicates…

• Double-Stapled Peptide Scan Yields Potent Fusion Inhibitors of Respiratory Syncytial Virus · 2026

  Résumé de la publication : Abstract Respiratory syncytial virus infection (RSV) is a major global health concern, particularly in infants and elderly populations. In this work, we have screened and identified 3 double-stapled peptides derived from a minimal domain of the RSV F heptad repeat, namely 3/4i,…

• Monoclonal antibodies targeting the rabies virus glycoprotein promotes viral clearance and Fc-dependent neuroprotection in the infected brain · 2026

  Résumé de la publication : Rabies is a complex disease that has defied efforts to develop an effective treatment. Although it can be successfully prevented through vector control or pre- or post-exposure prophylaxis, no therapeutic options exist for symptomatic rabies, and the disease is still responsible for…

• The bacterial type three secretion system induces mechanoporation of vacuolar membranes · 2025

  Résumé de la publication : Endomembrane breaching is a crucial strategy employed by intracellular pathogens enclosed within vacuoles to access the nutrient-rich cytosol for intracellular replication. While bacteria use various mechanisms to compromise host membranes, the specific processes and factors involved are often unknown. Shigella flexneri ,…