Unité de Biologie cellulaire des trypanosomes

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Développement d'une plateforme SHERLOCK pour le diagnostic et la surveillance de la maladie de Chagas · 2026

Publications HAL récentes repérées

• Human Leukocyte Antigen-G is enriched in presence of trypanosome in the dermis of individuals exposed to gambiense Human African Trypanosomiasis in Guinea and Côte d’Ivoire · 2026

  Résumé de la publication : Human leukocyte antigen-G (HLA-G) is an immunomodulatory molecule known to play a crucial role in immune tolerance and regulation. In the context of human African trypanosomiasis (HAT), higher soluble HLA-G levels were detected in the plasma of confirmed cases, representing a serological…

• Wnt and Nodal asymmetries stratify mouse laterality phenotypes in the absence of node flow · 2026

  Résumé de la publication : Abstract Left-right symmetry breaking in mice is considered to occur via node leftward fluid flow. The molecular cascade within the node has been reconstructed at high resolution. However, its importance for organogenesis remains poorly understood. Here we show in mutants for the…

• The IFT-A complex plays a major role in the assembly of anterograde intraflagellar transport trains · 2026

  Résumé de la publication : Abstract Cilia are assembled by intraflagellar transport (IFT), which relies on two protein complexes: IFT-A and IFT-B. It is generally assumed that IFT-B and IFT-A are critical for anterograde and retrograde transport, respectively. However, full deletion of IFT-A genes in several organisms…

• Stumpy forms are the predominant transmissible forms of Trypanosoma brucei · 2025

  Résumé de la publication : Schuster et al . demonstrated that bloodstream slender forms of African trypanosomes are readily transmissible to young tsetse flies where they can complete their complex life cycle (Schuster et al., 2021). In their experimental conditions, a single slender parasite was sufficient for…

• A new skin-on-chip model reveals biological adaptations of extravascular Trypanosoma brucei in the dermal microenvironment · 2025

  Résumé de la publication : Trypanosoma brucei sp. is an extracellular parasite causing human African trypanosomiases. It is transmitted to the mammalian host by tsetse flies during their blood meals. The fly deposits metacyclic trypomastigotes into the skin dermis. From there, the parasites enter the blood and…