Unité de Microenvironnement et Immunité

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Role du stroma dans le remodelage et fibrose du tissu adipeux · 2021
• La communication cerveau-intestin dans la potentiation de l’immunité mucosale · 2021

Publications HAL récentes repérées

• Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells · 2026

  Résumé de la publication : Prevention and regulation of excessive inflammation is a key target to protect against inflammatory pathologies such as autoimmunity and allergy. In a mouse model of acute lung protease hypersensitivity, we assessed the efficacy of immunological cross-regulation to mitigate pathogenic inflammation. We show…

• Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels · 2026

  Résumé de la publication : To investigate this, we developed a mouse model of surgical blockade of the cerebral venous outflow.Adult female mice underwent bilateral ligation of the internal and external jugular veins ( JVL mice) (Fig. 2a). The jugular veins are responsible for draining the cerebral…

• IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota · 2026

  Résumé de la publication : The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We report that in developing zebrafish, enteroendocrine cells produced interleukin-22 (IL-22) in response to microbial signals before…

• Selection for function in complex distributed pathological systems · 2026

  Résumé de la publication : Pathological processes are often conceptualized as localized phenomena anchored in a primary tumor, a focal lesion, or a single organ. However, growing evidence indicates that many diseases persist and progress as complex distributed systems, maintained by interactions among multiple sites. Building on…

• Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid · 2025

  Résumé de la publication : Intestinal crypts harbour a specific microbiota but whether and how these bacteria regulate intestinal stem cells (ISCs) or influence colorectal cancer (CRC) development is unclear. Here we screened crypt-resident bacteria in organoids and found that indole acetic acid (IAA) secreted by Acinetobacter…