Infection, anti-microbien, modélisation, évolution

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Chimie 3D innovante, mutagenèse exhaustive et modélisation intégrée pour anticiper et contrer l’évolution des carbapénémases de type Klebsiella pneumoniae carbapénèmase (KPC) · 2026
• Approche génomique intégrée pour étudier la résistance de Mycobacterium abscessus aux antimicrobiens et la diversité des souches infectant l’homme · 2026
• Contrôle épitranscriptomique de la colonisation et de la tolérance aux antibiotiques dans les infections urinaires · 2026

Publications HAL récentes repérées

• Comprehensive comparison of six optimization algorithms for automated population pharmacokinetic model selection via two simulation studies and eleven real case studies · 2027

  Résumé de la publication : Background and objectives: Prior efforts to automate population pharmacokinetic structural and statistical model selection have explored various algorithms with mixed results. This study is conducting a comprehensive comparison of six distinct optimization algorithms for selecting pharmacokinetic and target-mediated drug disposition models. Our…

• Attributable mortality of ICU-acquired bloodstream infections : Impact of the source, causative micro-organism, resistance profile and antimicrobial therapy · 2026

  Résumé de la publication : Objectives: ICU-acquired bloodstream infection (ICUBSI) in Intensive Care unit (ICU) is still associated with a high mortality rate. The increase of antimicrobial drug resistance makes its treatment increasingly challenging. Methods: We analyzed 571 ICU-BSI occurring amongst 10,734 patients who were prospectively included…

• Contribution of medical hypnosis via virtual reality in managing pain and anxiety in patients undergoing invasive sampling techniques for prenatal diagnosis: a prospective study · 2026

  Résumé de la publication : Introduction Amniocentesis and chorionic villus sampling (CVS) are perceived by patients as stressful and moderately painful. Few approaches improve their experience. This study assesses whether virtual reality–assisted medical hypnosis reduces procedural pain during these procedures, and examines its effects on anxiety, comfort,…

• Pre-existing β-lactamase gene diversity is associated with lower risk of ESBL-producing Enterobacterales colonization in patients exposed to ceftriaxone · 2026

  Résumé de la publication : Exposure to broad-spectrum antibiotics, particularly to third-generation cephalosporins (3GC), increases the risk of colonization by extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E). While clinical risk factors for ESBL-E acquisition are well established, the role of the gut microbiome and resistome remains unclear. We conducted a…

• Novel Drug‐Disease Modeling Framework for Oncology Benefit–Risk Evaluation: Application to Tusamitamab Ravtansine · 2026

  Résumé de la publication : This study introduces a novel drug-disease modeling framework designed to assess the benefit–risk balance of antibody-drug conjugates (ADC) in oncology. The framework integrates dose levels, pharmacokinetics, tumor growth dynamics, progression-free survival (PFS), and dose-adjusted adverse events. We demonstrated this through its application…