Laboratoire de recherche sur la croissance cellulaire, la réparation et la régénération tissulaires

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• HS3ST2 dans la pathologie tau liée à la maladie d’Alzheimer : approche génétique et pharmacologique pour la validation de la cible chez la souris · 2026
• Régulation de la réponse aux cytokines de la microglie et de la clairance de l'amyloïde induite par le remodelage des héparanes sulfates par Sulf2 · 2023
• Une thérapie matricielle pour optimiser la thérapie basée sur les vésicules extracellulaires dérivées de MSC pour protéger et réparer le cerveau ischémié · 2021

Publications HAL récentes repérées

• A novel TGFβ1–Hs3st2–tau axis regulates tau pathology and synaptic integrity · 2026

  Résumé de la publication : Introduction Tauopathies are a group of neurodegenerative diseases characterized by the pathological accumulation of tau protein. The hippocampus, a brain region crucial for learning and memory, is particularly susceptible to tau-induced damage. However, the molecular mechanisms underlying this vulnerability remain poorly understood.…

• A new promising anticancer agent: a glycosaminoglycan-mimetic derived from the marine bacterial infernan exopolysaccharide · 2025

  Résumé de la publication : Marine microorganisms are a promising source of innovative compounds for medical applications. The present study aimed to investigate anticancer potential of oversulfated low molecular weight derivatives, named OSIDs, prepared from infernan, a marine bacterial exopolysaccharide. In order to identify a lead, OSIDs…

• A new promising anticancer agent: A glycosaminoglycan-mimetic derived from the marine bacterial infernan exopolysaccharide · 2025

  Résumé de la publication : Marine microorganisms are a promising source of innovative compounds for medical applications. The present study aimed to investigate anticancer potential of oversulfated low molecular weight derivatives, named OSIDs, prepared from infernan, a marine bacterial exopolysaccharide. In order to identify a lead, OSIDs…

• Non-canonical nuclear function of glutaminase cooperates with Wnt signaling to drive EMT during neural crest development · 2025

  Résumé de la publication : Metabolic reprograming has been linked to epithelial-to-mesenchymal transition (EMT) in cancer cells, but how it influences EMT in normal cells remains largely unknown. Here we explored how metabolism impacts delamination and migration of avian trunk neural crest cells, an important progenitor cell…

• TRPC channels contribute to endothelial dysfunction in pulmonary arterial hypertension · 2025

  Résumé de la publication : Background-: Pulmonary arterial hypertension (PAH) is a rare, fatal, and progressive pulmonary vascular disease. Pulmonary endothelial cell dysfunction is a hallmark of PAH, defined by excessive proliferation and dysregulated angiogenesis, along with imbalanced production and release of vasoactive substances, growth factors, and…