MORPHOGÉNÈSE ET ANTIGÉNICITÉ DU VIH, DES VIRUS DES HÉPATITES ET ÉMERGENTS

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Étude des anticorps neutralisants pour le contrôle de l'infection par le VIH chez les participants traités tôt après la phase aiguë · 2026
• Mise au point d'un test rapide d'évaluation et de caractérisation de la réponse immune spécifiquement dirigée contre le Sars-Cov-2 · 2020
• Inhibition de l'interaction SARS-Cov2-S et ACE2 · 2020

Publications HAL récentes repérées

• Cholesterol Remodeling by CH25h Rewires IFITM3 Trafficking and Secretion Without Enhancing Antiviral Restriction · 2026

  Résumé de la publication : Type I interferon induces multiple protein effectors to inhibit viral replication. Among these, the interferon-induced transmembrane protein (IFITM3) and the cholesterol-25-hydroxylase (CH25h) converge on the inhibition of viral entry by altering the behavior of membranes. Here, we dissect the functional and mechanistic…

• Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt · 2026

  Résumé de la publication : The hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Although most infections are selflimiting, zoonotic genotypes can persist in immunocompromised individuals. Transmitted via the fecal-oral route, HEV has been suggested to directly infect the intestinal epithelium, a tissue…

• Improvement in staff behavior during surgical procedures to prevent postoperative complications (ARIBO 2 ) a cluster randomised trial · 2026

  Résumé de la publication : 2026 1 -Major adverse events: 16% patients admitted to hospital for surgery -49.3% related to surgical procedure -59% potentially, 21% probably preventable • Hip replacement, France: 9% adverse post-operative outcome • Surgical site infection → 14.3% of HAI (National PPS, 2022) •…

• Nicotinamide metabolism is essential for Hepatitis C Virus replication and the production of infectious Lipo-Viro-Particles · 2026

  Résumé de la publication : Background & aims: Hepatitis C virus (HCV) has the unique characteristic of forming lipo-viro-particles (LVPs), which are lipid-rich virions containing both the viral components and host apolipoproteins such as ApoB and E. This unique composition gives to LVPs a low buoyant density,…

• The role of Fibrillarin in HDV replication · 2026

  Résumé de la publication : HDV is a satellite virus that uses HBV envelope proteins to coat its ribonucleoprotein (RNP). Upon cell entry, the HDV RNP is transported to the nucleus, where replication of the HDV RNA takes place. Intra-nuclear HDV RNA replication is characterized by high…