PHYSIOPATHOLOGIE, AUTOIMMUNITE MALADIES NEUROMUSCULAIRES et THERAPIES REGENERATRICES

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Régulation des cellules B autoréactives par les lymphocytes T dans la physiopathologie du pemphigus · 2023
• Cibler P2X7 dans l'auto-immunité médiée par les cellules T · 2023
• Immunothérapie anti-tumorale basée sur l’utilisation de vecteurs AAV et leurs applications dans le traitement de tumeurs immunologiquement « froides ». · 2020

Publications HAL récentes repérées

• Preclinical evidence of anti-CD19 CAR-T cell in vitro and in vivo efficacy against CD19-expressing acute myeloid leukemia · 2026

  Résumé de la publication : Objective: Chimeric antigen receptor-modified T cell (CAR-T) therapy has demonstrated remarkable efficacy against refractory B-cell malignancies. This approach is more challenging in non-B-cell hematological malignancies such as acute myeloid leukemia (AML), especially because of target antigen selection difficulty and putative endogenous tumor…

• [Installation of Goubanne® in sterilization] · 2026

  Résumé de la publication : Good Hospital Pharmacy Practices require a daily saturated water vapor penetration test to be carried out. In 2021, preliminary work carried out at our facility highlighted the representativeness and sensitivity of Goubanne®. The aim is to roll it out for routine use…

• Development of an Ex Vivo Model of Focal Corneal Desiccation to Investigate the Pathophysiology of Corneal Dellen and Ulcers · 2026

  Résumé de la publication : Purpose: To determine the maximum extent of corneal thinning induced solely by dehydration and to establish the threshold at which corneal lysis begins, thereby refining therapeutic indications, with the aim of improving clinical management. Methods: Dehydration was induced in 28 corneas, after…

• Total body irradiation primes CD19-directed CAR T cells against large B-cell lymphoma · 2026

  Résumé de la publication : ABSTRACT CD19-targeting chimeric antigen receptor T cells (CART19) have demonstrated significant effectiveness in treating relapsed or refractory large B-cell lymphoma (LBCL). However, they often fail to sustain durable remissions in more than half of all treated patients. Therefore, there is an urgent…

• Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model · 2026

  Résumé de la publication : Cardiac lymphatics have emerged as potential targets in cardiovascular diseases (CVDs). However, we recently reported that despite extensive lymphatic expansion during experimental cardiac pressure-overload, lymphatic drainage remained insufficient. To unravel the cellular and molecular mechanisms underlying lymphatic dysfunction in CVDs, we applied…