Unité Biochimie des interactions macromoléculaires

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Structures et mécanisme de translocation de la toxine CyaA · 2021

Publications HAL récentes repérées

• Combinations of colistin and bacteriocins prevent the selection of colistin resistance in Acinetobacter baumannii · 2026

  Résumé de la publication : Acinetobacter baumannii is a multidrug-resistant nosocomial pathogen responsible for infections that are often difficult to treat. Here, we show that exposure of A. baumannii to the last-resort antibiotic colistin, which disrupts the outer membrane of Gram-negative bacteria, results in inner membrane permeabilization…

• Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity · 2026

  Résumé de la publication : Protein–protein interactions are central in all biological processes. Methods capable of detecting interactions within living, intact cells have been particularly useful to identify and characterize protein interaction networks. We describe here an exquisitely sensitive regulatory circuit that can detect in bacteria, protein–protein…

• Antibacterial Peptides Inhibit Lipoprotein Biogenesis by Targeting Membrane Phosphatidylglycerol · 2026

  Résumé de la publication : Prolipoprotein:phosphatidylglycerol diacylglyceryl transferase (Lgt) performs the first and committed step in the bacterial lipoprotein modification pathway by catalyzing the transfer of a diacylglyceryl moiety from diacylglycerol phospholipid onto pre-prolipoproteins. This enzyme is unique in bacteria and functionally and structurally highly conserved among…

• Structural determinants of endopilus assembly, stability, and functional specificity in bacterial type II secretion · 2026

  Résumé de la publication : Gram-negative bacteria employ the type II secretion system (T2SS) to transport folded protein effectors via a periplasmic helical polymer called the endopilus, composed of one major and four minor pilin subunits. Endopili resemble type IV pili but feature a conserved calcium-binding site…

• A Seven-Protein Assembly Promotes Stability, Neutralization and Secretion of the T7SSb LXG-effector TelE · 2026

  Résumé de la publication : Abstract Streptococcus gallolyticus subsp. gallolyticus (SGG) is a gut pathobiont associated with colorectal cancer. Like many Firmicutes, SGG utilizes a specialized Type VII Secretion System (T7SSb) to export WXG100 and LXG proteins, the latter involved in bacterial competition. We previously identified TelE,…