Unité de Biologie des infections virales émergentes

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Vaccins post exposition contre les virus emergents · 2021
• Les nucléases virales comme cibles thérapeutiques · 2018

Publications HAL récentes repérées

• Situation de la Fièvre Hémorragique de Crimée-Congo dans le sud de la France : intérêt d'une approche One Health · 2026

  Résumé de la publication : Depuis 2015, l’installation de la tique Hyalomma marginatum est largement documentée par les travaux du CIRAD en France continentale, notamment dans le sud, en lien avec le changement climatique et des dynamiques écologiques favorisant son expansion. Cette tique est un vecteur majeur…

• Lassa and Mopeia viruses produce different RIG-I-activating RNA in the absence of a functional viral exoribonuclease domain · 2026

  Résumé de la publication : All viruses of the genus Mammarenavirus possess an exoribonuclease (ExoN) domain in their nucleoproteins (NP). Through this domain, the NP efficiently prevents the activation of the interferon (IFN) response, presumably by degrading double-stranded RNA (dsRNA) produced during the viral replication. While the…

• Expansion of myeloid suppressor cells and suppression of Lassa virus-specific T cells during fatal Lassa fever · 2025

  Résumé de la publication : Lassa fever is a highly lethal hemorrhagic fever endemic to West Africa. In the absence of efficient prophylactic or therapeutic countermeasures, it poses a substantial threat to public health in this region. The pathophysiological mechanisms underlying the severity of the disease are…

• Fatal Lassa fever in cynomolgus monkeys is associated with systemic viral dissemination and inflammation · 2024

  Résumé de la publication : The pathogenesis of Lassa fever has not yet been fully deciphered, particularly as concerns the mechanisms determining whether acute infection is controlled or leads to catastrophic illness and death. Using a cynomolgus monkey model of Lassa virus (LASV) infection reproducing the different…

• Stable structures or PABP1 loading protects cellular and viral RNAs against ISG20-mediated decay · 2024

  Résumé de la publication : ISG20 is an IFN-induced 3′–5′ RNA exonuclease that acts as a broad antiviral factor. At present, the features that expose RNA to ISG20 remain unclear, although recent studies have pointed to the modulatory role of epitranscriptomic modifications in the susceptibility of target…