Unité de Dynamique du génome

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Hypomorphic mutations in ura6 confer 5-FOA resistance in fission yeast · 2026

  Résumé de la publication : Genome integrity is essential for cellular survival and adaptation across diverse physiological states. The fission yeast Schizosaccharomyces pombe relies on conserved DNA repair pathways to maintain genome stability during proliferative growth and in the absence of cell division (quiescence/G0). Using 5-fluoroorotic acid…

• Guidelines for Studying Mutagenesis in Quiescent Schizosaccharomyces pombe · 2026

  Résumé de la publication : All living organisms can enter a non‐dividing state known as quiescence, which often functions as a survival strategy. In many cases, quiescent cells retain the ability to re‐enter the cell cycle when conditions become favorable. Therefore, preserving the integrity of non‐dividing cells…

• Fast and accurate quantification of double-strand breaks in microsatellites by digital PCR · 2025

  Résumé de la publication : DNA double-strand breaks (DSBs) represent critical events in genome integrity, arising from both endogenous cellular processes and exogenous factors. These breaks are implicated in various genomic aberrations and chromosomal rearrangements, leading to cancers and genetic disorders. Common and rare fragile sites, containing…

• Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes · 2024

  Résumé de la publication : ABSTRACT Appropriate tuning of protein homeostasis through mobilization of the unfolded protein response (UPR) is key to the capacity of pancreatic beta cells to cope with highly variable demand for insulin synthesis. An efficient UPR ensures a sufficient beta cell mass and…

• Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes · 2024

  Résumé de la publication : Tuning of protein homeostasis through mobilization of the unfolded protein response (UPR) is key to the capacity of pancreatic beta cells to cope with variable demand for insulin. Here, we asked how insulin-degrading enzyme (IDE) affects beta cell adaptation to metabolic and…