PHENotypage et Ingénierie préCliniques des Systèmes chez les organismes modèles rongeurs

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Rspo1 dependent WNT signaling safeguards ovarian development by suppressing androgen signaling · 2026

  Résumé de la publication : Embryonic ovarian development requires high levels of WNT/B-catenin signaling yet the molecular basis of this requirement remains unclear. Mutations in the WNT potentiator RSPO1 impair ovarian development in both mouse and human, leading to gonadal masculinization in XX individuals. Here, we show…

• Cdkn2a/p16Ink4a loss impairs Spatial memory independently of Alzheimer’s-associated genetic pathways in young adult mice · 2026

  Résumé de la publication : Background The cyclin-dependent kinase inhibitor CDKN2A/p16INK4A (p16INK4A) is a central regulator of cellular senescence, widely studied in ageing and cancer. Although its expression increases with age and disease, its role in the adult brain remains poorly defined. Recent evidence suggests a possible…

• Age‐related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome · 2026

  Résumé de la publication : INTRODUCTION Down syndrome (DS) is the leading genetic cause of intellectual disability and Alzheimer's disease (AD), with over 90% of individuals developing AD-related dementia (DSAD). The triplication of the APP gene on chromosome 21 drives early amyloid-β (Aβ) accumulation, but other Hsa21…

• Standardized Pipeline for Metabolism and Cognition in GO‐DS21 Mouse Model: Investigating Down Syndrome Comorbidities · 2026

  Résumé de la publication : Down syndrome (DS) is the most prevalent form of intellectual disability (ID) globally, with an incidence rate of approximately 1 in 1000 births, affecting over 5 million individuals worldwide. DS is characterized by a genetic profile that predisposes individuals to a range…

• Manually and automatically annotated acoustic recordings of ultrasonic vocalisations of mice and rats · 2026

  Résumé de la publication : Rodents represent the most diverse mammalian taxon. They differ in their physiology, habitat and social systems. In this last domain, communication plays a crucial role. Acoustic communication in this taxon has driven high interest in the last decades, starting in the most…