NAnomédecine, Biologie extracellulaire, Intégratome et Innovations

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Nanovecteurs hybrides pour une délivrance optimisée de l’ARN messager · 2026
• Assemblage magnétique tolérogénique et anti-inflammatoire pour la modulation immunitaire dans les maladies auto-immunes · 2026
• Application des plasmas atmosphériques froids comme nouvelle approche thérapeutique de la fibrose hépatique et du remodelage des tissus · 2025

Publications HAL récentes repérées

• Rapid and efficient quality control analysis of isolated mitochondria by interferometric light microscopy · 2026

  Résumé de la publication : Abstract Mitochondrial transplantation is a promising biotherapeutic strategy to restore cellular energy homeostasis in diseases associated with mitochondrial dysfunction. However, its clinical translation is hindered by the lack of rapid, reliable, and label‐free techniques for quantifying and characterizing freshly isolated mitochondria. Current…

• A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production · 2026

  Résumé de la publication : Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs) have emerged as a promising cell‐free therapy due to their immunomodulatory and regenerative properties. However, scalable and standardized EV production remains a major bottleneck for clinical translation. A process based on repeated exposition to shear stress…

• Appendiceal Adenocarcinoma Discovered During Acute Perforated Appendicitis: A Potential Contribution of Prophylactic CRS and HIPEC - A French BIGRENAPE Group Study · 2026

  Résumé de la publication : Background: Treatment of peritoneal metastasis (PM) from appendicular adenocarcinoma consists of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). No specific recommendation exists in case of acute appendicular syndrome (AAS) with perforated tumor. Patients and methods: Data from 12 expert centers from…

• Building the melon pan-NLRome from nanopore Adaptive Sampling reads · 2026

  Résumé de la publication : Nucleotide-binding leucine-rich repeat (NLR) genes play a central role in plant immunity, but their clustered organization and high structural variability make them difficult to accurately resolve. • NLR genes make often part of the cloud pan-genome. CurrentreferencegenomesprovideonlyapartialviewofNLRdiversity. • Inmelon(Cucumismelo)andotherCucurbitaceae,asmallNLRrepertoirecontrastswithstrongpathogenpressure,andintraspecificNLRdiversityremainspoorlycharacterized. • The link…

• Selective mRNA Delivery to Activated Macrophages via Hyaluronic Acid-Functionalized Lipid Nanoparticles with Optimized PEGylation · 2026

  Résumé de la publication : Activated proinflammatory macrophages are associated with various inflammatory diseases, and due to their overexpression of the CD44 receptor, they may be targeted for therapy by hyaluronic acid (HA), its natural ligand. This study aimed to develop lipid nanoparticles (LNPs) functionalized with HA…