Unité d'Immunité Innée

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Durabilité des réponses immunitaires protectrices déclenchées par la primo-infection au SarS-Cov-2 chez les patients atteints de polyarthrite rhumatoïde ou de spondyloarthrite - Impact des traitements immunosuppresseurs · 2021
• Etude comparative des réponses anticorps muqueuses et systémiques contre le SRAS-Cov2 · 2021
• Etude des mécanismes d’un contrôle génétique de la thymopoïèse chez l’Homme. · 2021

Publications HAL récentes repérées

• Functional immune responses induced by a capsid assembly modulator in chronic hepatitis B virus-infected humanized mice · 2026

  Résumé de la publication : Current treatment strategies for hepatitis B virus (HBV) are lifelong and rarely curative. Finite therapeutic strategies aim to restore efficient immune responses in chronically infected patients for functional cures. Here, we investigate the impact of treatment with the capsid assembly modulator (CAM)…

• Clostridioides difficile Immunity During Pregnancy and Passive Antibody Transfer to Neonates from Cord Blood and Breast Milk · 2026

  Résumé de la publication : Passive transplacental immunity is crucial for neonatal protection from infections. Following Clostridioides difficile (C. difficile) infection, infants do not develop disease, although C. difficile colonization is highly prevalent in infants. This work aimed to characterize humoral immunity specific to C. difficile toxins…

• Tracking HIV-1 DNA fate from cell culture to humanized mice tissues · 2026

  Résumé de la publication : Unambiguous identification of HIV reservoirs is essential for their characterization and for developing curative strategies. A major obstacle to curing HIV is the persistence of silent viral genomes in host cells that evade immune detection and resist therapy. Here, we present a…

• The healthy human global project – Hong Kong: A community-based cross-sectional study of a healthy Asian population · 2026

  Résumé de la publication : Immune responses vary between individuals due to age, sex, genetics, and environment, yet most systems immunology studies focus on populations of European ancestry. To address this gap, we established the Healthy Human Global Project - Hong Kong (HHGP-HK) to characterize immune variability…

• Variability in the TLR3 type I interferon pathway is predictive of RNA vaccine responses · 2026

  Résumé de la publication : Biological predictors of variable vaccine responses are lacking. We hypothesized that variability in prevaccine innate immune responses, specifically for type I interferons (IFN-I), is predictive of postvaccine antigen-specific responses. To test this, we assessed prevaccine immune responses at protein and transcriptomic levels…