Institut de Génétique Humaine

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Rôle des clusters de piARN dans l’élimination de l’ADN médiée par l’ARN · 2026
• Identification de vulnérabilités métaboliques dans le Myélome Multiple · 2025
• Impact des mitochondries et du réseau d’actine sur l'organisation fonctionnelle des granules germinaux. · 2025

Publications HAL récentes repérées

• Co-translational determination of quaternary structures in chaperone factories · 2026

  Résumé de la publication : The HSP90/R2TP quaternary chaperone assembles key cellular machines, including the three nuclear RNA polymerases and many non-coding RNPs. Here, we characterize the RNAs associated with R2TP and find that it binds many proteins co-translationally. Its co-translational interactome reveals potential clients and distinguishes…

• Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding · 2026

  Résumé de la publication : Epigenetic memory enables the propagation of gene expression patterns following transient stimuli. Although three-dimensional chromatin organization is emerging as a key regulator of genome function, it is unknown whether it contributes to cellular memory. Here we establish that acute perturbation of the…

• Neuron-secreted chemokine-like Orion interacts with the glial receptor Draper during mushroom body neuronal remodeling in Drosophila · 2026

  Résumé de la publication : Across the animal kingdom, neuronal remodeling is a crucial developmental mechanism to refine neurite targeting necessary for both maturation and function of neural circuits. The neuronal chemokine-like Orion is essential for astrocyte infiltration and likely for phagocytosis during mushroom body γ-neuron remodeling…

• Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression · 2026

  Résumé de la publication : T-prolymphocytic leukemia (T-PLL) typically presents with rapidly progressing tumor burden. However, 15–25% of cases are diagnosed at an indolent stage with asymptomatic and stable low-level blood lymphocytosis over up to 2-3 years before advancing to active-stage disease. To define the molecular changes…

• A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity · 2026

  Résumé de la publication : Chromatin modulators, like Polycomb group proteins, are key epigenetic regulators of gene expression and are frequently mutated in cancers. In adult stem cells, epigenetic regulation maintains their identity and controls their differentiation during homeostasis or aging, but its direct role in tumorigenesis…