SFR Biosciences

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella · 2026

  Résumé de la publication : Abstract IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2 KO mice and demonstrate that they are equally susceptible to Francisella…

• Thyroid hormones maintain parvalbumin neuron functions in the mouse neocortex · 2026

  Résumé de la publication : Parvalbumin-expressing GABAergic interneurons are crucial for maintaining excitation/inhibition balance in the neocortex. The postnatal maturation of parvalbumin neurons is highly sensitive to thyroid hormone deficiency. The present study addressed the role of thyroid hormones in mature parvalbumin neurons. Using genetically modified mouse…

• Thyroid hormones act as a timer for the postnatal maturation of parvalbumin neurons in the neocortex · 2026

  Résumé de la publication : Thyroid hormones (THs) are required for proper maturation of parvalbumin-expressing GABAergic interneurons in the mouse neocortex, which function is essential to maintain a proper balance between neuronal excitation and inhibition. However, the timeline of this TH action has yet to be elucidated.…

• A Hox-dependent anchoring mechanism mediates transcriptional repression of autophagy-related genes at the nuclear periphery · 2026

  Résumé de la publication : The spatial organization of the genome within the nucleus is critical for gene regulation, yet the mechanisms by which transcription factors (TFs) orchestrate this process remain poorly understood. Here, we demonstrate that the Drosophila Hox protein Ultrabithorax (Ubx) represses autophagy-related ( atg…

• Versatile lipoparticles for the co-delivery of TLR3 and TLR7/8 ligands as vaccine adjuvants: in vitro and in vivo evaluations · 2026

  Résumé de la publication : Recent subunit vaccines based on purified protein antigens have shown reduced immunogenicity and efficacy, highlighting the need for adjuvants to improve the level and quality of the induced immune responses. Toll-like receptors (TLR) are innate immunity receptors that represent promising targets for…