Unité de Microbiologie structurale

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Caractérisation mécanistique de sous-complexes du divisome bactérien reconstitués in vitro · 2021
• Régulation du cycle cellulaire de Sinorhizobium et efficacité de la symbiose avec les légumineuses · 2021

Publications HAL récentes repérées

• Mechanistic insights into SteAB regulation of cell wall hydrolase RipA in Mycobacterium tuberculosis · 2026

  Résumé de la publication : D,L-endopeptidase RipA is the major peptidoglycan (PG) hydrolase required for cell separation in Mycobacterium tuberculosis (Mtb), as RipA defects severely hinder cell division and increase antibiotic vulnerability. Despite extensive studies, the mechanisms governing Mtb RipA regulation remain controversial and poorly understood. Here,…

• Monoclonal antibodies against nitrated nerve growth factor reveal an oxidation-dependent pathogenic hallmark in ALS · 2026

  Résumé de la publication : Significance Nerve growth factor (NGF) is a trophic factor essential for neuronal maintenance and survival. Its function can be compromised by oxidative posttranslational modifications, in particular tyrosine nitration. Protein 3-nitrotyrosine is associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). In…

• A Seven-Protein Assembly Promotes Stability, Neutralization and Secretion of the T7SSb LXG-effector TelE · 2026

  Résumé de la publication : Abstract Streptococcus gallolyticus subsp. gallolyticus (SGG) is a gut pathobiont associated with colorectal cancer. Like many Firmicutes, SGG utilizes a specialized Type VII Secretion System (T7SSb) to export WXG100 and LXG proteins, the latter involved in bacterial competition. We previously identified TelE,…

• Functional dissection of Corynebacterium glutamicum Wag31 domains for septal recruitment and polar distribution during the cell cycle · 2026

  Résumé de la publication : Bacterial cell morphogenesis is controlled by the synthesis and organization of peptidoglycan and driven by multi-protein complexes, such as the divisome and elongasome. Here, we investigate the role of the Corynebacterium glutamicum DivIVA homolog, Wag31, the elongasome scaffold that is required for…

• The orphan receptor GPR84 drives inflammation in Buruli ulcer development · 2026

  Résumé de la publication : Inflammatory responses can be of critical importance in determining both the course and outcome of infectious diseases. Buruli ulcer, a neglected tropical disease caused by (), has been reported to induce both immunosuppressive and proinflammatory responses in the skin. Here, we found…