Laboratoire de biologie et pharmacologie appliquée

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Caractérisation des nouveaux ligands de pyrine · 2026
• Exploration du mécanisme de dépliement des acides nucléiques par la protéine Cellular Nucleic acid Binding Protein (CNBP) · 2026
• Déchiffrage de mécanismes de réaction aux antibiotiques par un système à deux composants chez les bactéries · 2024

Publications HAL récentes repérées

• Suppression of bacterial cell death underlies the antagonistic interaction between ciprofloxacin and tetracycline inEscherichia coli · 2026

  Résumé de la publication : Antibiotic combinations are an attractive strategy to maximise the efficiency of drug treatment and minimise resistance evolution, but we still lack a full understanding of their effect on bacterial cells. The interaction between DNA-targeting antibiotics, such as ciprofloxacin, and translation inhibitors, such…

• The cytokinesis regulator RacGAP1 is a Rac1‐specific GAP on membranes · 2026

  Résumé de la publication : Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many cellular and biochemical studies, whether RhoA or…

• Working with C. difficile in a Hypoxic Chamber · 2026

  Résumé de la publication : Clostridioides difficile is an enteropathogen responsible for diarrhea under conditions leading to a dysbiosis of the gut microbiota, in particular after an antibiotic treatment. It is a spore-forming obligate anaerobe, which is, as such, usually cultivated in anaerobiosis in laboratories. Yet the…

• Effect of TAR hairpin stabilization on HIV-1 reverse transcription · 2026

  Résumé de la publication : ABSTRACT Reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome requires the first strand transfer that relies on a base-pairing interaction between the 3′ R sequence of the genomic RNA (gRNA) and the r sequence of the strong-stop DNA (ssDNA).…

• BRCA1-RAD51 homologous DNA repair pathway promotes HIV-1 reverse transcription · 2026

  Résumé de la publication : HIV-1 infection triggers multiple cellular pathways that modulate viral replication and may promote latency. Central to this process is the reverse transcription of the viral RNA into DNA and its integration into host chromatin, both processes being regulated by the cell. Emerging…