Unité de Technologies Chimiques et Biologiques pour la santé

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Thérapie Génique de la maladie de Gaucher neuronopathique · 2024
• Nanothermométrie optique pour le contrôle et la compréhension de phénomènes magnéto-induits. Application à l’hyperthermie biologique et à la catalyse hétérogène en solution · 2021
• PARK-PEP: Ciblage de la phosphorylation de LRRK2 par peptides interférents en modèles experimentaux de la maladie de Parkinson · 2021

Publications HAL récentes repérées

• Circulating Transcriptome Analysis Finds Gene Signatures and Immune Cell Activation and Abundance Predict Response to Immunotherapy in Bladder Cancer · 2026

  Résumé de la publication : PURPOSE: Immune checkpoint blockers (ICB) have revolutionized oncology by achieving durable tumor responses in advanced cancers. Nevertheless, currently approved biomarkers (PD-L1, microsatellite instability, and tumor mutational burden) have suboptimal positive and negative predictive values for tumor response and survival. EXPERIMENTAL DESIGN: We…

• Purification and Transcriptomic Characterization of Hypertrophied Hepatic Stellate Cells From CDAHFD Mouse Liver · 2026

  Résumé de la publication : Hepatic stellate cells (HSC) are known for their major role in hepatic fibrosis. It is well established that upon liver injury, they undergo a transition from a quiescent state to an activated state and transdifferentiate into proliferative, fibrogenic myofibroblasts. Recently, it has…

• Study of synergistic tumor toxicity in pancreatic cancer cells through liposomal drug combination therapy · 2026

  Résumé de la publication : Pancreatic cancer is a lethal malignancy, frequently diagnosed at an advanced stage due to its asymptomatic progression. Current combinatorial therapies show the benefits of the multi-drug approach; however, the side effects of these therapeutic protocols remain severe. Therefore, there is an urgent…

• Machine Learning for the Prediction of Size and Encapsulation Efficiency of mRNA-Loaded Lipid Nanoparticles Following a Postencapsulation Approach · 2026

  Résumé de la publication : Lipid nanoparticles (LNPs) have gained significant attention thanks to their ability to encapsulate and deliver mRNA. Exploring a variety of lipid compositions and different preparation processes is essential for a better understanding of the mRNA encapsulation and the LNPs assembly. In this…

• DNase I-Conjugated Cerium Oxide Nanoparticle-Based Treatment to Improve Thrombolysis · 2026

  Résumé de la publication : Ischemic stroke, caused by the occlusion of a cerebral artery by a thrombus, remains a major global health concern. While recombinant tissue plasminogen activator (rtPA) is the only approved pharmacological treatment for thrombolysis, its limited efficacy stresses the pressing need for a…