Laboratoire

CENTRE DE RECHERCHE DES CORDELIERS

CRC

Biologie, médecine et santé. Les publications HAL repérées abordent notamment Immunotherapy, Cancer, Hepatocellular carcinoma.

Domaines et travaux documentés

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Domaines scientifiques déclarés au RNSR

Biologie, médecine et santé

Panels ERC déclarés au RNSR

Molecules of Life: Biological Mechanisms, Structures and Functions : Molecular biology, biochemistry, structural biology, molecular biophysics, synthetic and chemical biology, drug design, innovative methods and modellingIntegrative Biology: from Genes and Genomes to Systems : Genetics, epigenetics, genomics and other ‘omics studies, bioinformatics, systems biology, genetic diseases, gene editing, innovative methods and modelling, ‘omics for personalised medicineCell Biology, Development, Stem Cells and Regeneration : Structure and function of the cell, cell-cell communication, embryogenesis, tissue differentiation, organogenesis, growth, development, evolution of development, organoids, stem cells, regeneration, therapeutic approachesPhysiology in Health, Disease and Ageing : Organ and tissue physiology, comparative physiology, physiology of ageing, pathophysiology, inter-organ and tissue communication, endocrinology, nutrition, metabolism, interaction with the microbiome, non-communicable diseases including cancer (and except disorders of the nervous system and immunity-related diseases)Immunity, Infection and Immunotherapy : The immune system, related disorders and their mechanisms, biology of infectious agents and infection, biological basis of prevention and treatment of infectious diseases, innovative immunological tools and approaches, including therapies

Mots-clés des publications HAL repérées

ImmunotherapyCancerHepatocellular carcinomaAutophagyColorectal cancerMetabolismMachine learningInflammationArtificial intelligenceChemotherapyComplementObesity

Projets ANR

Publications HAL récentes repérées

Nivolumab in Metastatic Clear-cell Renal Cell Carcinoma: An Integrative Biomarker Analysis from the NIVOREN GETUG-AFU 26 Phase 2 Study · 2026
Résumé de la publication : Nivolumab improved survival in patients with refractory metastatic clear-cell renal cell carcinoma (ccRCC), but no reliable biomarker of activity has been identified. We conducted a real-world phase 2 trial of nivolumab in patients progressing after one or more vascular endothelial growth factor…
Complement activation drives a compartmentalized innate immune response in C3 glomerulopathy contributing to the disease phenotype · 2026
Résumé de la publication : Introduction: C3 glomerulopathy is a rare kidney disease resulting from dysregulation of the complement alternative pathway. The mechanistic diversity of alternative pathway activation, the heterogeneous immunological and clinical profiles limit a comprehensive understanding of the disease. Methods: Here, we characterize mechanisms of…
Identification of antihypertensive, antidiabetic, and antioxidant peptides derived from hydrolysates of dairy white wastewaters containing milk proteins using machine learning insights · 2026
Résumé de la publication : Dairy white wastewater (WW), a by-product of industrial cleaning processes, contains residual milk proteins that can be enzymatically converted into bioactive peptides. In this study, WW proteins were hydrolyzed using four enzymes, pepsin, trypsin, thermolysin, and pronase E, for up to 240 min,…
Total Thrombus Formation system exploration of primary haemostasis in cirrhotic patients · 2026
Résumé de la publication : Background: Primary hemostasis is impaired in cirrhosis, characterized by thrombocytopenia, platelet dysfunction, elevated von Willebrand Factor (VWF) levels, and reduced a disintegrin-like metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) activity. Current clinical hemostasis tests assess biological parameters individually or use static clot…
Novel assays to assess the prevalence and neutralizing potential of anti-IdeS antibodies in healthy humans · 2026
Résumé de la publication : Background: The IgG-degrading enzyme IdeS (imlifidase) is a cysteine protease produced by Streptococcus pyogenes. It specifically hydrolyzes human IgG, cleaving the molecule to separate the F(ab’)2 fragment from the Fc region, thereby promoting IgG catabolism. The therapeutic form of IdeS (Idefirix®) is…

Projets européens

ICD-Cancer — Immunogenic cell death (ICD) in the cancer-immune dialogue
Horizon Europe · Appel 2021 · Structure associée au projet
The success of most if not all anticancer treatments depends on the (re)activation of immunosurveillance, as this has been documented for several therapeutic modalities, not only immunotherapy, but also chemotherapy, targeted therapy and radiotherapy. In response to antineoplastic drugs, malignant cells can undergo immunogenic cell death (ICD), thus exposing and releasing danger signals that act…

Implantations

Adresse RNSR : CENTRE BIOMEDICAL DES CORDELIERS, 15 RUE DE L'ECOLE DE MEDECINE, bat. b, 75270, Paris, France

Regroupements

Ce laboratoire est inclus dans le périmètre de recherche des regroupements suivants, directement ou par son rattachement institutionnel.

PUI — Université Paris Cité · PUI

Liens et rattachements

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CENTRE DE RECHERCHE DES CORDELIERS

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Sources et actualisation

Site de la structure · RNSR · HAL

Fiche mise à jour: 09/10/2026

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