Laboratoire d'Innovation Moléculaire et Applications (LIMA)

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Polyrotaxanes à séquence définie construits à partir de macromonomères incluant du pillar[5]arène · 2026
• Inhibiteurs covalents ciblant des enzymes actives sur les sucres : conception de novo pour une forte sélectivité · 2026
• Ingénierie enzymatique pour la production microbienne de pyoverdines améliorées pour des applications biomédicales. · 2025

Publications HAL récentes repérées

• (NHC-olefin)-nickel(0) nanoparticles: an efficient and selective catalyst for hydrogenation reactions at low temperature and pressure · 2026

  Résumé de la publication : The reduction of a NHC-cinnamyl nickel(II) organometallic complex through the use of different MeMgBr or MeMgCl reagents led to two types of NHC-olefin-coordinated nickel nanoparticles. Both of these unsupported nickel-NHC based nanomaterials behaved under hydrogen pressure as effective and selective catalysts operating…

• Tannin-coated polyurethane foams as a non-innocent structured support for Pd-catalysed alkyne semi-hydrogenation, nitroarene reduction and Suzuki coupling under air · 2026

  Résumé de la publication : Polyurethane foams (PUF) were coated with hydrolyzable (HT) or condensed (CT) tannins, derived from chesnut and quebracho woods, and Pd was anchored onto the HT or CT layer via simple immersion of HT@PUF and CT@PUF in a water-ethanol (1:5) solution of Pd(NH3)4Cl2H2O…

• From cyclic diaryl λ 3 -bromanes/chloranes to polyfuntionalized biarylsilanes via aryne σ-bonds · 2026

  Résumé de la publication : While biarylsilanes are intriguing compounds with emerging applications, their synthesis is far from trivial. Herein, we report an unprecedented strategy that allows access to these challenging compounds under metal-free and mild conditions with full atom economy using cyclic diaryl bromanes and chloranes…

• Multifaceted biological and computational assessment of aromatic and N-heteroaromatic non-substituted thiosemicarbazones · 2026

  Résumé de la publication : Thiosemicarbazones (TSCs) constitute a pharmacologically versatile class of compounds with documented antimicrobial, antiviral, and anticancer properties. Despite their therapeutic potential, their biological mechanisms and pharmacokinetic behaviour remain insufficiently characterized. In this study, we investigated the biological activity of the library consisting of…

• Natural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum · 2026

  Résumé de la publication : Background: Malaria is a deadly parasitic disease for which innovative treatments are urgently needed. A mixture of eight triterpenic esters (8TTE) was previously identified as important for the antiplasmodial activity of Keetia leucantha twigs, a plant used in traditional medicine in Benin.…