Dynamique des Génomes et Adaptation Microbienne

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Caractérisation d’une nouvelle voie de réparation des mésappariements · 2022
• Caractérisation fonctionnelle d'un réseau de protéines nécessaire à la différenciation cellulaire et à l’établissement de « patterns » chez la cyanobactérie Nostoc PCC 7120 · 2021
• Exploration du lien entre structure-composition-fonction au sein du génome compartimenté de Streptomyces · 2021

Publications HAL récentes repérées

• Co-option of an ancestral peptidase controls developmental patterning in multicellular cyanobacteria · 2026

  Résumé de la publication : Spatial patterning in multicellular organisms is commonly explained by Turing-type reaction-diffusion systems, but the maturation of diffusible inhibitors remains poorly understood. In the cyanobacterium Nostoc PCC 7120, nitrogen deprivation triggers a pattern of nitrogen-fixing heterocysts regulated by HetR and inhibitory peptides, including…

• A modular genetic toolbox for precise gene regulation and multi-color imaging in streptococci · 2026

  Résumé de la publication : Fluorescent labeling is a powerful tool in microbiology allowing live cell imaging and providing insights into dynamic cellular processes, quantification of gene expression, and protein subcellular localization. Although multicolor imaging is widely used in Streptococcus pneumoniae and S. mutans , this is…

• Macrolide resistance determinants and their associations in streptococci from selected livestock and wildlife species from Catalonia, Northeast Spain · 2026

  Résumé de la publication : The increasing macrolide resistance in Streptococcus spp. causing human and animal infections in the last decades is a concern for global health. The objectives of this study were to analyze the macrolide resistance rates of Streptococcus spp. from animals and their resistance…

• Evidence of transfer of antimicrobial resistance genes from the porcine pathogen Streptococcus suis to human clinical isolates of Streptococcus agalactiae in a major pig-producing region of Spain · 2026

  Résumé de la publication : The emergence of antimicrobial resistance (AMR) is a global threat, with livestock antibiotic use proposed as a significant contributor. We investigated Streptococcus suis, a multidrug-resistant porcine pathogen, as a potential source of AMR gene dissemination to human-associated streptococci in Aragón, Spain. Among…

• Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues · 2025

  Résumé de la publication : The polyketide specialized metabolites of bacteria are attractive targets for generating analogues, with the goal of improving their pharmaceutical properties. Here, we aimed to produce C-26 derivatives of the giant anti-cancer stambomycin macrolides using a mutasynthesis approach, as this position has been…