Chimie Analytique et Réactivité Moléculaire En Normandie

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Signalisation de la vitamine A au niveau de la cellule unique dans des conditions physiologiques et pathologiques · 2026
• Modèles de fondation hyperspectraux pour l'analyse des sols · 2025
• Couplage entre l’impression 3D et le frittage SPS pour la fabrication de matériaux ultra-réfractaires de formes complexes · 2025

Publications HAL récentes repérées

• 4,5-Dihydro-2H-pyridazin-3-ones as a Platform for the Construction of Chiral 4,4-Disubstituted-dihydropyridazin-3-ones · 2026

  Résumé de la publication : 4,5-Dihydro-2H-pyridazin-3-ones (DHPDOs) are important synthetic as well as naturally occurring heterocycles. We herein report the synthesis of various 4-monofunctionalized 4,5dihydro-2H-pyridazin-3-ones and their use as starting materials to access 4,4-disubstituted dihydropyridazin-3-ones in an asymmetric fashion. By using chiral ammonium salt phasetransfer catalysts, conjugate…

• Planar Chiral Sulfur Compound Derived from [2.2]Paracyclophane: Synthesis and Applications · 2026

  Résumé de la publication : Over the past decade, planar chiral sulfur-containing [2.2]paracyclophanes have attracted increasing attention. This review offers a comprehensive overview of the strategies developed to access these appealing derivatives, along with their diverse applications in fields ranging from catalysis to materials science. The discussion…

• A Sequential Iodination–Fluorodeiodination of the Cubane Scaffold · 2026

  Résumé de la publication : The synthesis of fluorinated cubane derivatives is described via a two-step cubane iodination–fluorodeiodination sequence. The conversion of iodocubane into fluorocubane was found to be possible by using Selectfluor, thus avoiding the use of hazardous xenon difluoride and allowing fluorocubane synthesis using standard…

• Parallel Sequencing of the Two Arms on a Bispecific Antibody by Electron Capture Dissociation on a timsOmni Platform Reveals Several By-products in the Controlled Fab-arm Exchange Process · 2026

  Résumé de la publication : Bispecific antibodies (bsAbs) can simultaneously target two distinct antigens, offering enhanced therapeutic efficacy compared to conventional antibodies. However, their complex manufacturing process, involving pairing of four distinct polypeptide chains (two heavy and two light chains), enhances the analytical challenges in quality control.…

• Pilosibacter rotomagensis sp. nov., a Butyrate-Producing Bacterium Isolated from Human Faeces · 2026

  Résumé de la publication : Isolating bacteria from the human gut microbiota and analyzing their phenotypes is essential for complementing the data obtained by metagenomics and for characterizing the functions of these microorganisms in human physiology. In this study, we isolated bacteria from the gut microbiota of…