Chimie et Modélisation pour la Biologie du Cancer, UMR9187-U1196

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Pertinence biologique et ciblage de l’ADN i-motif · 2021

Publications HAL récentes repérées

• Compounds of the γ-carboline family inhibit trans-translation · 2026

  Résumé de la publication : Background and objectives: Because antimicrobial resistance is one of the most pressing global health challenges of our time, it is crucial to find and develop new antimicrobial compounds, especially molecules with new targets and mechanisms of action. Among those, trans-translation, the main…

• IGF-1 receptor ATP-competitive inhibitors for the treatment of Ewing sarcoma: a comprehensive virtual screening analysis for a dataset of molecules showing a wide range of chemical structures · 2026

  Résumé de la publication : We report an integrated computational workflow combining QSAR modelling, structure-based virtual screening and molecular dynamics to characterize 114 IGF-1R ATP-competitive inhibitors. A five-descriptor QSAR model (RCI, P_VSA_LogP_3, Eta_sh_y, nCbH and LOGPcons) identified compounds 9, 32, 34 and 100 as the most potent…

• Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life · 2026

  Résumé de la publication : Archaea, a domain of microorganisms found in diverse environments, including the human microbiome, represent the closest known prokaryotic relatives of eukaryotes. This phylogenetic proximity positions them as a relevant model for investigating the evolutionary origins of nucleic acid secondary structures such as…

• Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1) · 2026

  Résumé de la publication : Myotonic dystrophy type 1 (DM1) is caused by expanded CTG repeats, d(CTG) exp , transcribed into toxic r(CUG) exp RNA repeats that sequester splicing regulator MBNL1, leading to its loss‐of‐function. An emerging therapeutic strategy toward DM1 treatment relies on the inhibition of…

• Do G4 ligands induce mitochondrial dysfunction without ROS induction · 2026

  Résumé de la publication : G-quadruplex (G4) DNA structures, present in both nuclear and mitochondrial genomes, represent emerging therapeutic targets. Here, we developed and exploited a mitochondrial high-content profiling platform (Mito-HiCP), integrating automated microscopy with quantitative image analysis, to compare the effects of G4 ligands with cisplatin…