Center of translational and molecular medicine

Domaines scientifiques déclarés au RNSR

Panels ERC déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Interaction entre les dérivés lipoprotéines et AzaBODIPY : de la rationalisation à la conception d'une sonde fluorescente NIR spécifique sans biovecteur optimisée · 2025
• Lipides associés aux vésicules extracellulaires, vers de nouvelles cibles théranostiques de la fibrose pulmonaire idiopathique · 2025
• Décrypter le contrôle épigénétique du développement et de la fonction des cellules T innées ab · 2025

Publications HAL récentes repérées

• Neurological and psychiatric issues in 187 adults with early-treated PKU: The ECOPHEN study · 2026

  Résumé de la publication : Introduction: Phenylketonuria (PKU) is an autosomal recessive disorder caused by mutations in the PAH gene leading to phenylalanine hydroxylase deficiency. This results in the accumulation of phenylalanine (Phe) in blood and brain, causing neurological and psychiatric impairments if untreated. Newborn screening (NBS)…

• Experimental evolution of Plasmodium yoelii in single and helminth-coinfected mice. · 2026

  Résumé de la publication : Background Coinfection has the potential to affect key traits describing the infection dynamics, the severity of the disease and in fine parasite fitness. However, despite its pervasiveness, experimental work investigating how parasites adapt to the conditions provided by a coinfected host is…

• Randomized, multicenter Phase III trial of adjuvant chemotherapy with modified FOLFIRINOX versus capecitabine or gemcitabine in patients with resected ampullary adenocarcinoma · 2026

  Résumé de la publication : Background: Ampullary adenocarcinoma (AAC) is a rare and aggressive cancer with a 5-year overall survival (OS) rate ranging from 30% to 67% after resection due to a high recurrence rate. Yet, adjuvant therapy's role is still debated. Recent French FFCD-AC cohort study…

• Cytokine Release Symptoms rather than Syndromes: A call for Granular Reporting of Cytokine Related Adverse Events in Clinical Trials · 2026

  Résumé de la publication : Background: T-cell redirecting therapies, notably CAR T-cells and bispecific antibodies, have revolutionized the treatment of hematologic malignancies. Their rapid expansion into solid tumors, alongside the emergence of next-generation agents, such as immunocytokines and CD28-costimulatory bispecifics, has brought Cytokine Release Syndrome (CRS) to…

• Surgical Management of Zollinger‐Ellison Syndrome in Multiple Endocrine Neoplasia Type 1 an AFCE and GTE Cohort Study. (Association Francophone de Chirurgie Endocrinienne and Groupe d'étude des Tumeurs Endocrines) · 2026

  Résumé de la publication : ABSTRACT Objective To describe surgical indications, procedures and outcomes in patients operated for Zollinger‐Ellison syndrome (ZES) in multiple endocrine neoplasia type 1 (MEN1) using a large nationwide cohort. Background Management of ZES in MEN1 remains controversial. Methods All patients with ZES diagnosed…