Plate-Forme de Criblage chémogénomique et biologique

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• KREMEN2, un nouvel inhibiteur de l'auto-inflammation médié par NF-kB impliqué dans les maladies généiques humaines · 2021

Publications HAL récentes repérées

• Semi-automated Detection of Late Cytokinetic Bridges · 2026

  Résumé de la publication : During cytoplasmic division, the intercellular bridge is formed with a central midbody. In our opinion, more tools are required for investigation of the late molecular events leading to cytokinetic abscission. In this chapter, we briefly review the many available methods to screen…

• Deep learning extracts MoA-specific signatures from high-throughput images of chemically and genetically perturbed Corynebacteria · 2026

  Résumé de la publication : Tuberculosis (TB) is the worldwide leading infectious killer due to a single pathogen and increasing antimicrobial resistance (AMR) makes it imperative to discover and develop new drugs with novel modes of action (MoAs) to treat TB infections. Phenotypic screening of chemical libraries…

• Noncovalent Inhibitors of SARS-CoV-2 Main Protease: A Rescaffolding Attempt · 2025

  Résumé de la publication : Out of the results of the sole large-scale screening for inhibitors of SARS-CoV-1 main protease reported in 2013, attempts to improve the identified 3-pyridyl-bearing hits have been conducted in research laboratories, either on this enzyme or more recently on the closely related…

• Deep learning recognises antibiotic modes of action from brightfield images · 2025

  Résumé de la publication : Abstract Antimicrobial resistance is a growing public health threat predicted to cause up to 10 million deaths a year by 2050. To circumvent existing bacterial resistance mechanisms, discovering antibiotics with novel modes of action (MoAs) is crucial. While growth inhibition assays can…

• Design, synthesis, biophysical and biological evaluation of original condensed pyrrolopyrimidine and pyrrolopyridine ligands as anti-SARS-CoV-2 agents targeting G4 · 2025

  Résumé de la publication : The design and synthesis of novel bis[(substituted-aminomethyl)phenyl]phenyl pyrrolopyrimidines, pyrrolopyridines, pyrazolopyrimidines, imidazopyrimidines, and tris[(substituted-aminomethyl)phenyl]phenyl pyrrolopyrimidines are reported here. These original G-quadruplex (G4) ligands have been then subjected to a screening on SARS-CoV-2 using a competition HTRF assay by targeting the SUD-NM/TRF2 RNA G4…