Unité de biologie moléculaire, cellulaire et du développement

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Analyse de l’hétérochromatine péricentromérique : vers une meilleure compréhension de la relation structure-fonction · 2026
• Etude du rôle des G-quadruplexes (G4) comme mécanosenseurs nucléaires en réponse à la dynamique du cytosquelette · 2026
• Control Physique de la transcription lors de la delamination des cellules · 2026

Publications HAL récentes repérées

• Functional impact of the eIF6 N106S mutation on ribosome biogenesis in wild type and Shwachman–Diamond syndrome cells · 2026

  Résumé de la publication : Background: Eukaryotic initiation factor 6 (eIF6) is an essential regulator of ribosome biogenesis that prevents the premature association of the 60S and 40S ribosomal subunits. eIF6 eviction from nascent 60S particles, mediated by the ribosome biogenesis factors SBDS and EFL1, is required…

• Loss of Snord115 mitigates Snord116-driven sleep abnormalities in mouse models of Prader-Willi syndrome · 2026

  Résumé de la publication : Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the loss of paternally expressed genes within the imprinted 15q11-q13 locus, which includes clusters of box C/D small nucleolar RNAs (SNORDs), notably the SNORD115 and SNORD116 gene families. Although SNORD116 deletions have been…

• Expanding the Phenotypic Spectrum Associated With Loss‐of‐Function SMARCA4 Variants to Eye Developmental Anomalies · 2026

  Résumé de la publication : The SMARCA4 gene encodes a catalytic subunit of the BRG1/BRM‐associated factor complex, which regulates gene expression through chromatin remodeling. Heterozygous missense variants in this gene have been linked to Coffin–Siris syndrome, characterized by intellectual development disorder and various congenital anomalies (distinctive facial…

• Four women whose pioneering contributions to science have been largely overlooked · 2026

  Résumé de la publication : Ethel Browne Harvey and Hilde Pröscholdt Mangold did pioneering research in embryology, Ida Henrietta Hyde helped develop the first microelectrodes for the stimulation of single cells, and Marthe Gautier had a vital role in discovering that Down syndrome is caused by an…

• Drosophila melanogaster miPEP8 regulates cell size through its interaction with ref(2)P/p62 · 2026

  Résumé de la publication : MiPEPs are microproteins encoded by primary transcripts of microRNAs (pri-miRNAs). Initially identified in plants, we recently characterized a miPEP in Drosophila melanogaster , named miPEP8, which is involved in the regulation of wing size. However, mechanisms at play are unknown. In the…