Institut national de la sante et de la recherche medicale

Projets européens

• SyncyNucDiff — The biology of syncytial cells: Dissecting the mechanisms and functions of nuclear differentiation inside skeletal muscle syncytium

  Horizon Europe · Appel 2021 · Établissement bénéficiaire (ERC)

  Due to their cellular anatomy, syncytial cells face many unique challenges that mono-nucleated cells do not. One of them is how syncytial cells organize gene expression among many nuclei in a shared cytoplasm. How such property is linked to their biological functions remains poorly understood. Using the skeletal muscle as a paradigm and single-nucleus transcriptomics,…

• REGENECREST — Enhancing endogenous regenerative response in mammals by redeploying Cranial Neural Crest Cells pluripotency developmental programs and positional identity remodeling

  Horizon Europe · Appel 2021 · Établissement bénéficiaire (ERC)

  Cell differentiation progresses via a continuous lineage restriction process where cell potential is reduced as the embryo develops. Pluripotent embryonic cells can beget all somatic cell types, but this capacity is rapidly restricted during the formation of the three germ layers, each giving rise to distinct cell types. Uniquely among vertebrates, a stem cell-like population…

• Cytok-Gut — Cytokine and microbiota function in gut development: spatiotemporal analysis in the zebrafish

  Horizon Europe · Appel 2021 · Établissement bénéficiaire (ERC)

  Organ development and function are controlled by complex interactions between genetic, cellular, and environmental factors. Because these interactions are challenging to study in live organisms, their mechanisms remain largely unknown. Gut development is regulated by microbiota colonization, making it a valuable organ for dissecting gene-environment interactions. Cytokines, small secreted proteins highly responsive to environmental changes,…

• EpiDetect — Detecting epigenetic biomarkers in the blood for non-invasive precision oncology

  Horizon Europe · Appel 2021 · Établissement bénéficiaire (ERC)

  The detection of circulating tumor DNA allows to non-invasively retrieve tumor molecular profiles and follow disease evolution. These approaches promise optimal and individualized management of patients with cancer. However, despite remarkable progress, several technological obstacles still limit liquid biopsy widespread application. Indeed, detecting small fractions of tumor DNA released when the tumor burden is reduced…

• MicroflowLife — Whole-organ 3D ultrasound micro-flow imaging: from basics physics to clinical proof-of-concept on cardiac and cerebral diseases

  Horizon Europe · Appel 2021 · Établissement bénéficiaire (ERC)

  Blood circulation is essential to organs’ functions and occurs through a complex network of vessels with diameters varying from several millimetres for large arteries to only a few microns for small capillaries. Dysfunctions in the microcirculation are early markers of many diseases, which are however diagnosed at later stage, when observable symptoms become visible at…