Unité Individualité Microbienne et Infection

Domaines scientifiques déclarés au RNSR

Publications HAL récentes repérées

• Automated Optimization of Bacterial Tracking Pipelines with TrackMate 8 · 2026

  Résumé de la publication : Quantitative analysis of bacterial dynamics in time-lapse microscopy requires robust tracking pipelines, yet selecting and optimizing algorithms for specific experiments remains challenging. Indeed, Microbiologists are confronted with numerous algorithms that must be carefully chosen and parameterized to achieve optimal tracking for their…

• Stress-responsive Mycobacterium tuberculosis subpopulations manipulate macrophage polarization and can be targeted to limit inflammation · 2026

  Résumé de la publication : Tuberculosis is characterized by broad clinical heterogeneity that hinders infection control, with differences in lesion development, progression, and treatment outcomes. This complexity is likely associated with Mycobacterium tuberculosis inherent phenotypic variation and its capacity to diversify under host microenvironmental and antimicrobial stressors.…

• Data Management Plan · 2024

  Résumé de la publication : V02 -TREATABLE (ANR-21-CE15-0045)TREATABLE project focuses on tuberculosis that remains a major global-health threat, further exacerbated by the COVID-19 pandemic. Because phenotypic variation supports the tubercular pathogen in enduring drug therapy, we propose to further validate the molecular bases of this phenomenon, and…

• Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy · 2024

  Résumé de la publication : Abstract Drug-recalcitrant infections are a leading global-health concern. Bacterial cells benefit from phenotypic variation, which can suggest effective antimicrobial strategies. However, probing phenotypic variation entails spatiotemporal analysis of individual cells that is technically challenging, and hard to integrate into drug discovery. In…

• RNase E and HupB dynamics foster mycobacterial cell homeostasis and fitness · 2022

  Résumé de la publication : RNA turnover is a primary source of gene expression variation, in turn promoting cellular adaptation. Mycobacteria leverage reversible mRNA stabilization to endure hostile conditions. Although RNase E is essential for RNA turnover in several species, its role in mycobacterial single-cell physiology and…