Unité Immunologie Translationnelle

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Caractérisation moléculaire et cellulaire de l'immunomodulation médiée par CXCR4: implication dans les maladies auto-immunes · 2021

Publications HAL récentes repérées

• Human Macrophages Secrete Both Interferon α and Interferon β Proteins During Infection with Mycobacterium tuberculosis · 2026

  Résumé de la publication : Mycobacterium tuberculosis (Mtb) infection activates type I interferons (IFNs), which are crucial mediators of tuberculosis pathogenesis. Despite assumptions that IFNα and IFNβ are secreted by human macrophages, direct protein quantification in primary monocyte-derived macrophages (MDMs) is surprisingly lacking. Here, we demonstrate measurable…

• Aspergillus and host-pathogen interaction: focus on treatment-relevant aspects · 2026

  Résumé de la publication : Background Invasive aspergillosis (IA) remains a major cause of morbidity and mortality in immunocompromised individuals, with an expanding spectrum of at-risk populations, particularly in intensive care settings. Despite advances in antifungal pharmacotherapy, treatment outcomes remain suboptimal, and the rise of antifungal resistance…

• Baseline interferon signaling in monocytes and antibody-mediated innate activation are associated with reactogenicity to mRNA vaccines · 2026

  Résumé de la publication : The local and systemic symptoms that follow vaccination, collectively referred to as reactogenicity, are common, yet the mechanisms underlying individual variability remain poorly understood. Through longitudinal immune profiling of vaccinated individuals and mechanistic studies in mice, we identified key immunological determinants of…

• Modeling neonatal immune response to B. pertussis identifies early B cell activation and differentiation · 2026

  Résumé de la publication : Pertussis is typically more severe in neonates and young infants, with fulminant forms possibly linked to age-specific systemic immune responses. However, the early events that shape the development of the immune response in neonates are poorly understood, mainly due to limited sample…

• Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses · 2026

  Résumé de la publication : Antibodies are central to immune defenses. Despite advances in understanding the mechanisms of antibody generation, a comprehensive model of how intrinsic and external factors shape human humoral responses to viruses has been lacking. Here we apply phage immunoprecipitation sequencing to investigate the…