Unité Chimie bioorganique des acides nucléiques

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Towards the enzymatic labelling of oligonucleotides with triantennary N-acetyl galactosamine · 2026

  Résumé de la publication : The introduction of chemical modifications into oligonucleotides enhances backbone stability against nuclease degradation and improves biological activity. Although achieving cell-, tissue-, and organ-specific delivery remains challenging, conjugation to triantennary N-acetylgalactosamine (triGalNAc) ligands enables receptor-mediated delivery of nucleic acids to hepatocytes. TriGalNAc ligands…

• A Pair of DNA Glucosyltransferases Elevate Counter-defense in Bacteriophage T4 · 2026

  Résumé de la publication : Bacteriophages encode diverse pathways to modify their nucleobases. These modifications help phages to evade the host defense systems such as restriction-modification (RM), and type II and type V CRISPR-Cas systems. On the other hand, modifications can also serve as a target for…

• A pair of DNA glucosyltransferases elevate counter-defense in bacteriophage T4 · 2026

  Résumé de la publication : Bacteriophages encode diverse nucleotide-modification pathways to evade host restriction-modification (RM) and CRISPR–Cas systems. On the other hand, modifications can also serve as a target for host defense systems, illustrating the complexity of the defense and counter defense landscape. Bacteriophage T4 encodes two…

• Enzymatic Synthesis of Glyco-DNA Equipped with Oligosaccharides and Charged Monosaccharides · 2026

  Résumé de la publication : The therapeutic and biotechnological utility of synthetic oligonucleotides is constrained by the limited chemical diversity of canonical nucleotides and their susceptibility to nuclease degradation. Inspired by the hypermodified genomes of bacteriophages, where 5-glycosylated pyrimidines confer protection against host restriction enzymes, we report…

• Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality · 2026

  Résumé de la publication : Chemical modifications expand the functional repertoire of nucleic acids, but the extent to which complex glycans can be integrated into genetic polymers remains largely unexplored. Glycosylated nucleic acids, including glycoRNAs and bacteriophage genomes, are emerging as key mediators of host-pathogen interactions, yet…