Unité Chromatine et Infection

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Pneumococcus uses COMMD2 to alter host cellular immunity · 2026

  Résumé de la publication : NF-κB driven cellular immunity is essential for both pro- and anti-inflammatory responses to microbes, which makes it one of the most frequently targeted pathways by bacteria during pathogenesis. How NF-κB tunes the epithelial response to Streptococcus pneumoniae across the spectrum of commensal…

• Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity · 2025

  Résumé de la publication : Nasopharyngeal colonisation by Streptococcus pneumoniae is characterised by adherence to epithelial cells, microinvasion and innate immune activation. Previously, we have shown that two biosynthesis gene mutants of S. pneumoniae serotype 6B strain ( ΔproABC and Δfhs with an additional ΔpiaA mutation) can…

• Host epigenetic mechanisms targeted by Streptococcus pneumoniae to maintain the di-methylation at lysine 4 of histone H3 (H3K4me2) in respiratory epithelial cells · 2025

  Résumé de la publication : Upon infection, bacteria subvert host cell transcriptional responses. One of the mechanisms thought to mediate transcriptional changes are post-translational modifications of histones. This research project studies an infection-induced histone modification maintained beyond bacterial presence. Streptococcus pneumoniae is a Gram-positive bacterium which colonizes…

• Selection of Ruthenium Polypyridyl Complex-Modified Aptamers for Photodynamic Therapy against Streptococcus Pneumonia · 2025

  Résumé de la publication : Photodynamic therapy (PDT) harnesses the combination of light, oxygen, and photosensitizers to induce cell death via reactive oxygen species (ROS) formation. Given its intrinsic properties, PDT represents an alluring way of stymieing the increasing surge of antimicrobial resistance (AMR). Despite favorable assets,…

• NK cells undergo transcriptional and functional reprogramming following Streptococcus pneumoniae infection · 2025

  Résumé de la publication : Natural Killer (NK) cells are cytotoxic lymphocytes and key mediators of innate immunity, essential for combating viral infections and cancer. Notably, they exhibit immunological memory, generating a stronger response upon re-exposure to the same stimulus. While NK cell memory holds promise for…