Unité Mécanismes de l'hérédité épigénétique

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny · 2026

  Résumé de la publication : At the onset of reproduction, oviparous animals synthesize large amounts of yolk in somatic tissues to provide lipids and other nutrients to their progeny. However, whether the yolk transports other molecules, such as RNAs with gene-regulatory functions, remains largely unexplored. Here, we…

• Intraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegans · 2026

  Résumé de la publication : Epigenetic inheritance is generally less stable across generations than DNA sequence-based heredity. One common form of epigenetic inheritance, found in plants, fungi, and animals, is the transgenerational memory of gene silencing mediated by small RNAs. These small RNAs can be amplified through…

• DNA supercoiling modulates eukaryotic transcription in a gene-orientation dependent manner · 2025

  Résumé de la publication : Summary Transcription introduces torsional stress in the DNA fiber causing it to transition from a relaxed to a supercoiled state that can propagate across several kilobases and modulate the binding and activity of DNA-associated proteins. As a result, transcription at one locus…

• H3K27me3 expands the epigenetic control of piRNA transcription · 2025

  Résumé de la publication : Constitutive heterochromatin can promote piRNA transcription, a crucial step in genome defense. Two studies now show that piRNA transcription in Drosophila is regulated by the dual histone marks H3K27me3 and H3K9me3, and piRNA transcription in Caenorhabditis elegans is enhanced by H3K27me3, gene…

• Soma-to-Germline miRNA inheritance via Yolk Promotes Stress Resilience in Progeny · 2025

  Résumé de la publication : Inheritance is typically viewed as a genetic process; however, accumulating evidence suggests that epigenetic mechanisms—particularly small RNAs—can also transmit acquired traits across generation. Recent studies suggests that environmental cues, such as stress or diet, can reshape the small RNA content of gametes,…