PRODUCTION ET ANALYSE DES DONNEES EN SCIENCES DE LA VIE ET EN SANTE

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Immunopathologie du COVID-19 à l'Assistance Publique Hôpitaux de Paris · 2020

Publications HAL récentes repérées

• Association between the site of emergency care and patient-centered outcomes in patients with cancer: rationale and design of the French COVER cohort · 2026

  Résumé de la publication : Patients living with cancer now account for a substantial and growing share of emergency department (ED) visits and carry a high burden of hospitalization and in-hospital death. Their acute presentations are frequently multifactorial – driven by disease progression, treatment toxicity, immunosuppression, or…

• PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization · 2026

  Résumé de la publication : While acute promyelocytic leukemia (APL) is always driven by fusions involving one of the three retinoic acid receptors, why PML and RARA are the preferred fusion partners has remained largely unsettled. Here, we demonstrate that corepressor (NCoR) binding onto the RARA moiety…

• Characterisation of the new microalgal protein xATPA related to the F-type ATP synthase α subunit, from the ecosystem to the molecule · 2026

  Résumé de la publication : Microalgal metabolism relies on their chloroplasts, and involves both nucleus and plastidial-encoded proteins of various evolutionary origins. The plastidial ATP synthase complex is a key player in photosynthesis, and has been extensively studied in plants. However, our knowledge in other photosynthetic eukaryotes…

• Dysregulated dsRNA sensor signaling and viral infection during onset of pediatric autoimmune interferonopathy · 2026

  Résumé de la publication : Juvenile dermatomyositis (JDM) is characterized by a type I interferon (IFN-I) signature associated with disease activity. We previously identified a link between SARS-CoV-2 infection and the onset or relapse of JDM. Here, we show that newly diagnosed JDM patients display an overexpression…

• Blood Transfusion in Patients With Acute Myocardial Infarction, Anemia, and Heart Failure: Lessons From MINT · 2025

  Résumé de la publication : BACKGROUND: Blood transfusion may precipitate adverse outcomes, including heart failure (HF), among patients with acute myocardial infarction (MI). This study characterizes the effects of a restrictive or liberal transfusion strategy on outcomes in patients with MI and anemia with and without baseline…