Unité Biologie de Synthèse

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Publications HAL récentes repérées

• A CRISPR-Cas9 method for selectively eliminating plasmids in enterobacteria · 2026

  Résumé de la publication : Understanding the factors driving the success of plasmid-bacteria associations is crucial to tackle the plasmid-mediated antimicrobial resistance. A major challenge in studying plasmid-bacteria associations is the difficulty of removing plasmids from wild-type clinical bacteria, which often carry different plasmids per cell. Here,…

• Shuttling, swapping and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellites · 2026

  Résumé de la publication : Interactions between bacteria, bacteriophages, and their satellites are shaped by a myriad of defence and counter-defence mechanisms. Here, we identified and characterized the defence hotspots of thousands of P2-like phages and P4-like satellites to elucidate the origins and evolutionary dynamics of defence…

• Shuttling, swapping, and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellites · 2026

  Résumé de la publication : Abstract Interactions between bacteria, bacteriophages, and their satellites are shaped by a myriad of defence and counter-defence mechanisms. Here, we identified and characterized the defence hotspots of thousands of P2-like phages and P4-like satellites to elucidate the origins and evolutionary dynamics of…

• Evolutionary Advantage of Diversity-Generating Retroelements in Switching Environments · 2026

  Résumé de la publication : Diversity-Generating Retroelements (DGRs) create rapid, targeted variation within specific genomic regions in phages and bacteria. They operate through stochastic retro-transcription of a template region (TR) into a variable region (VR), which typically encodes ligand-binding proteins. Despite their prevalence, the evolutionary conditions that…

• Diversity-generating retroelements for programmable targeted hypermutagenesis · 2026

  Résumé de la publication : Diversity-generating retroelements (DGRs) are natural systems that accelerate the evolution of diverse bacterial functions through targeted hypermutation. We establish a method using DGRs coupled to recombineering (DGRec), which enables the diversification of any sequence of interest in Escherichia coli. Detailed characterization of…