Unité Epigénomique, Prolifération et Identité Cellulaire

Domaines scientifiques déclarés au RNSR

Mots-clés des publications HAL repérées

Projets ANR

• Bookmarking, les tests ultimes d’une hypothèse · 2026

Publications HAL récentes repérées

• Topological Regulation of the Mammalian Genome by Positive DNA Supercoiling · 2026

  Résumé de la publication : DNA supercoiling is a fundamental aspect of genome topology characterizing all DNA transactions. While negative supercoiling has been extensively characterized, positive supercoiling remains poorly understood. Using a quantitative GapR profiling system, we establish comprehensive maps of positive supercoiling across interphase and mitosis.…

• Transposable Element insertions Repurpose Immune Endonucleases as Drivers of Reproductive Isolation in Mice · 2026

  Résumé de la publication : The emergence of reproductive barriers between closely related populations is a fundamental step in speciation, yet the underlying genetic mechanisms remain poorly understood in mammals. Here we resolve the DDK syndrome, a long-standing model of hybrid incompatibility in mice, by showing that…

• Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters · 2026

  Résumé de la publication : Faithful genome reactivation after mitosis is essential for cell identity, yet the mechanisms driving global postmitotic transcription remain unclear. Here, we show that the MYC oncogene and its obligate partner MAX drive a postmitotic hypertranscriptional state in mouse embryonic stem cells. Cell…

• Transcriptomic profiling reveals similarities between equine IVF and ICSI embryos · 2026

  Résumé de la publication : In vitro production of equine embryos has been performed using intracytoplasmic sperm injection (ICSI) for the last two decades. Since 2022, a repeatable protocol for conventional in vitro fertilization (IVF) provides a successful alternative. However, little is known about the influence of…

• [Preview] Embryo and prejudice: From diverse first transcriptional impressions to a common developmental path · 2025

  Résumé de la publication : Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, Zhang et al. studied RNA Pol II…